Hemoglobin-based oxygen carrier

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HBOC

How it works?

Developed based on the proprietary Oxyplus Technology Platform (OTP), these oxygen-active protein conjugates are manufactured using cGMP state-of-the-art biotechnology from source-verified biological materials and are capable of oxygen carriage in the plasma space of blood as a perfusion agent to help secure the oxygen carrying protein distribution to various capillary beds not accessible to larger or rigid red blood cells. It also allows for distribution to poorly oxygenated regions permitting higher oxygen tensions and reduction of hypoxic/ischemic conditions in cells.

Scope

Due to the smaller size of Hemoglobin-based Oxygen Carrier (HBOC) (appropriately 1/5000 of red blood cells), HBOC helps secure the oxygen carrying protein distribution to various capillary beds and occulation not accessible to larger or rigid red blood cells. It is indicated that during low blood pressure, HBOC can provide more oxygen and better tissue oxygenated than red blood cells.

Safety

Source-verified raw material combined with world leading hemoglobin isolation and purification technology as well as viral-removal process, which provide us high purified and high potent native hemoglobin; via chemical modification and cross-linked stabilization process, along with quality control and assurance system, all of which make HBOC a suitable particle size distribution, greatly improve its safety.

Effective

When getting into body, HBOC circulates in plasma and rapidly increases plasma hemoglobin and total hemoglobin concentrations, it also allows for distribution to poorly oxygenated regions and provides tissues with sufficient oxygen perfusion. For oxygen delivery capacity, HBOC is 3 times greater red blood cell, meanwhile it can steadily improve the oxygen transport capacity of red blood cells.

Availability

In contrast to red blood cell, HBOC can be store at Room temperature for more than 3 years; moreover, there is no need for cold chain transport and cross-matching. In case of emergency, patients can be treated more promptly.

HBOC

Broad application prospects

HBOC is not only the volume expander for stable hemodynamics, but is also the oxygen therapeutic for enhancing the perfusion of tissue and organs; In addition to blood substitute for trauma, it can also be used for resuscitation of cardio-cerebrovascular diseases. HBOC is high purity, high potency hemoglobin polymers, which is stabilized trough inter-molecular and intra-molecular cross-linking, and the technology is the state-of-art around the world. The product has many USES such as the prevention and treatment organ necrosis, national defense and national medical reserve, organ in vitro protection and so on, which can meet a variety of medical needs and promote the medical level of our country.

Prevention of tissue necrosis

For regional hypoxia of tissue and organ, as long as the hypoxia reaches a certain intensity or duration, can lead to cease of cell metabolism and ultimately cause tissue necrosis and cell death. HBOC can increase plasma hemoglobin concentration in an extremely short time; can improve artery oxygen content, transporting oxygen into hypoxia organ or tissue so as to effectively prevent or treat tissue cell necrosis and reduce the incidence of complications.

Blood function substitute

HBOC meets all the standards of ideal blood substitute, which include low immunogenicity, no need for cross-matching, universal compatible, low risk for disease transmission, acceptable safety, and its efficacy is not inferior to red blood cell. Therefore, HBOC is not only the volume expander for the stable hemodynamic, but also the oxygen therapy agent to strengthen the tissue and organ perfusion, so as to replace the function of red blood cells.

National defense and national pharmaceutical reserve

It can be incorporated into the national pharmaceutical reserve program to respond to disasters, outbreaks and emergencies that cause widespread casualties among people. HBOC has high efficacy, small toxicity and very stable nature, and at room temperature it can be preserved for up to 3 years. It is a national strategic product of "combination of peace and war, civilian and military dual-use".

Endangered animals

Since HBOC product got market approval in Europe and United States, has been popular and loved by companion animal customers and wildlife protection agencies. The first generation product was sold more than 300,000 units in both Europe and United States, helped to save nearly 100,000 different kinds of animals. It has an unrivalled advantage in the resuscitation of rare animals, especially those with high value of rare animals and military animals.

Anti-tumor adjunctive therapy

HBOC as an oxygen therapeutic can be applied to adjuvant therapy for tumors, which can not only enhance the treatment effect of radiation and chemotherapy (as sensitization agent), but also relieve anemia symptoms of cancer patients caused by various reasons such as tumor and radio-chemotherapy.

Organ preservation

RedPharmRx®is a breakthrough innovation for organ preservation. This oxygen carrier developed by Redpharm Therapeutics allows better organ preservation by oxygenating the transplant organ. The main benefits of RedPharmRx® include the possibility of treating more patients who are waiting for organ transplants and a better patient prognosis after the transplant. Preliminary tests have shown that patient prognosis is better when RedPharmRx®is used and that the transplant success rate is higher.

HBOC

Huge market capacity

HBOC has a huge market prospect and huge market capacity in the prevention and control of cardiovascular disease.

Cardiovascular Disease

10 seconds

China

per death

  • 230 million patients with cardiovascular disease
  • 50% growth rate/year
  • 16 million deaths/year
  • 2.5 million new cases/year

capacity of the market

20 billions

China

HBOC

  • 6 billion for blood substitute
  • 4 billion for national defense and National pharmaceutical reserve
  • 10 billion for prevention and treatment of tissue necrosis
  • 20 billions for total capacity of the market

Pet market

97.8 billion

China

capacity of the market

  • 23% of the pet medical industry
  • 500 million for pet pharmaceutical market capacity
  • 200 million for endangered and research animal market capacity
  • 100 million for military service animal market capacity

organ transplantation

2.6%

Global

Growth rate of organ transplantation

  • 130000 in 2017
  • 300,000 organ transplants per year in China
  • 27 cases/day(China)
  • 1 billion USD market capacity for organ preservative solution or medium

Hear What Experts Say.

  • expert image
    CARL Chief Scientist

    Oxygen therapeutic products have several advantages compared with packed red blood cells, including a prolonged shelf-life, lack of a cross-matching requirement, and minimal infectious risks or concerns about immunogenicity.

  • expert image
    Jingang Zhang Expert Consulter

    HBOC has both the abilities of oxygen delivery and replenishment of blood colloid osmotic pressure; smaller molecular size can make it easily traverse vascular stenosis or partial of capillary thrombus. HBOCs have an extremely wide application prospect and market value: application prospects such as prevention and treatment organ necrosis,blood function substitute, national defense and national medical reserve, rare wildlife protection, organ in vitro protection and so on, which can meet a variety of medical needs and promote the medical level of our country.

HBOC

Questions and Answers.

Q1: When administration of HBOCs, is it necessary to perform type-matching test?

Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates, it is the only non-membrane protein that does not comprise of any antigenic determinant for blood type, thus, it is not necessary for cross-matching when administration.

Q2: What are the potential indications and applications of HBOC?

HBOCs have broad prospects, including anti-hemorrhage therapy such as traumatic hemorrhagic shock; anti-anemia therapy includes anemia symptoms caused by various reasons; anti-tumor adjunct therapy; organ preservative solution etc.

Q3: Why HBOC can traverse capillary end and vascular embolism?

HBOC is 1/5000 times the size of RBC with lower viscosity, this stabilized hemoglobin can go through obstructed blood vessels and end-size capillaries to supply oxygen to tissues in need.

Q4: What is the function mechanism of HBOC?

HBOC can on-load oxygen from alveolar with high oxygen pressure, and along with the blood circulation, release oxygen into the tissues with lower oxygen pressure, thus HBOC functions as oxygen delivery.

Q5: What makes HBOC can be store up to 3 years at room temperature?

The leading isolation and purification technology combined with stable chemical modifications, all of which make the quality of the HBOC controllable. Meanwhile, with the protection of inert gas during the whole process, the oxyhemoglobin rate is extremely low, which greatly reduces the self-oxidation rate of hemoglobin and improves product stability.

Q6: What are the strategic implications of HBOC?

HBOC is not only the volume expander for stable hemodynamics, but is also the oxygen therapeutic for enhancing the perfusion of tissue and organs; In addition to blood substitute for trauma, it can also be used for resuscitation of cardio-cerebrovascular diseases. HBOC has high efficacy, small toxicity and very stable nature, and at room temperature it can be preserved for up to 3 years. It is a national strategic product of "combination of peace and war, civilian and military dual-use".

HBOC Applied Surgical Video

In some people's view, Hemoglobin-based oxygen carrier is only a supplement to blood transfusion; but in the view of a surgeon, oxygen-carrying hemoglobin is another safeguard for the patient's life.